Tumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and mice.

In one recent study, there was a nonsignificant trend toward an increase in nonenhancing tumor progression in patients treated with bevacizumab compared with those treated with nonantiangiogenic therapy. 13 Continuous blockade of VEGF-induced vascular proliferation may promote tumor “escape” through vascular co-option, which may radiographically manifest itself as infiltrative, nonenhancing FLAIR progression.

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