Rank-rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures.

In Figure 2 I, the RRHO map shows that borderline significant overlap is present between the human breast cancer ER-positive signature and the HER2 mouse model of breast cancer.

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The heatmap output of RRHO is colored by the direction-signed log 10 -transformed hypergeometric P -values so high positive intensity areas indicate highly significant overlap of the ranked lists and high negative intensity indicates lower than expected overlap.

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