Second, phase resolution of haplotypes of TOMM40 polymorphisms in R2 with the linked APOE ɛ4 or ɛ3 allele revealed a highly significant difference in the distribution of the APOE alleles and genotypes and TOMM40 haplotypes between clades A and B on the tree.
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A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease.
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The sentences
The ORs for disease risk for each clade B allele, in all cases the minor allele, suggested that the clade B alleles are protective of AD risk in the AS cohort, although in each case the association narrowly missed significance.