Given the central role of JAK2 signaling to a myriad of cellular processes, there may be significant toxicities associated with JAK2 inhibition, and “off-target” inhibition of JAK1, JAK3, or TYK2 might lead to hematologic, immunologic, and endocrine side effects.
← all excerpts
ZFP36L1 negatively regulates erythroid differentiation of CD34+ hematopoietic stem cells by interfering with the Stat5b pathway.
1
—
—