Controlled trials in children: quantity, methodological quality and descriptive characteristics of pediatric controlled trials published 1948-2006.

Methodological Quality Methodological quality as assessed by the Jadad score increased significantly over time (P<0.0001); we also reanalyzed the data minus the first period (1948–1953) (where the average Jadad score was much lower) and the increase over time was still highly significant (p = 0.0002) ( Figure 4 ).

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