As compared to the empty vector, HNF6 transfection caused a highly significant cell cycle arrest in the G2/M phase in Caco-2 cells ( Fig. 7A ) and in the G1 an S-phase of HepG2 cells, respectively ( Fig.7B ).
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Inhibition of the liver enriched protein FOXA2 recovers HNF6 activity in human colon carcinoma and liver hepatoma cells.
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