Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease.

Immunized 17 month old female mice reveal a decreasing trend in brain Aβ We wished to determine whether these results were due either to sex or to amyloid burden, as the female 3 × tg AD mice have a significantly greater amyloid load compared to male mice of the same age [ 18 ].

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We found that PFA1-immunized 17 month old female mice revealed a significant 34% increase in Aβ42 (p < 0.05), and an increasing trend (140%) in Aβ40, following treatment (Fig. 8A & 8B ).

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