Ticagrelor: an investigational oral antiplatelet treatment for reduction of major adverse cardiac events in patients with acute coronary syndrome.

In the second International Study of Infarct Survival (ISIS-2) in patients with ST segment elevation myocardial infarction (STEMI), the use of aspirin as opposed to placebo was associated with a highly significant reduction in vascular mortality (9.4% versus 11.8%, P < 0.00001) along with significant reduction in rates of reinfarction (1.0% versus 2.0%) and nonfatal stroke (0.3% versus 0.6%) at five weeks. 6 Blockade of the P2Y 12 subtype of adenosine diphosphate (ADP) receptor on platelet cell membranes ( Figure 1 ) has been established as another key mechanism of platelet inhibition.

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