Common variants of TLR1 associate with organ dysfunction and sustained pro-inflammatory responses during sepsis.

PLoS One · 2010 · PMC2966434 · PMID 21048935

Europe PMC DOI

hedged sentences

0.0610

closest p · 1.2× alpha

0.0610

boldest claim

The sentences

borderline significancep = 0.061so close (0.05 < p ≤ 0.1)

The associations for Asn248Ser and Ser602Ile also persisted when adjusting for covariates (OR for 248Ser: 2.13, 95% CI: 1.16–3.90, p = 0.015; OR for 602Ile: 1.94, 95% CI: 1.10–3.44, p = 0.023) and showed borderline significance after the conservative adjustment for population stratification ( p = 0.061 for Asn248Ser and p = 0.064 for Ser602Ile).

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barely significantno p-value reported

This analysis supported the strong correlation of TLR1 SNPs with CRP and IL-10 levels observed before, while revealed barely significant relationships of TLR1 SNPs with IL-6 and IL-1β levels ( Table S3 ), indicating that GLM results were not as biased as predicted.

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