MGMT gene promoter methylation correlates with tolerance of temozolomide treatment in melanoma but not with clinical outcome.

Ma et al (2003) retrospectively investigated, by immunohistochemistry, MGMT protein expression in melanoma metastases of 79 patients with metastatic melanoma receiving DTIC as single agent or as part of combination therapy, and reported an inverse correlation between MGMT expression and clinical response with borderline significance ( P =0.05).

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In glioblastoma patients, the correlation between DNA methylation in tumour tissue and free circulating DNA of sera was highly significant ( Balana et al , 2003 ; Ramirez et al , 2003 ).

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