highly significantp<.001
(1981) evaluated subjects after 4 hours, 14 hours and 7 days and reported improvement rates of 40%, 38% and 65% respectively. Escobar & Barron (1983), Dubin et al. (1985), Nishikawa & Tsudo (1985), Neto et al. (1988), Coryell & Kelly (1990) and Volavka (1992) have also reported significant improvement rates of 65%, 73%, 70%, 55% and 67% respectively after 7 days in the high dose group. In the present study too, patients in the high dose group showed highly significant improvement (p<.001) from the baseline at all the evaluations.