A highly significant decrease in the detection of the JHC-1-specific epitope was observed at 4, 6, 8, and 12 h postdose at plasma levels of dalcetrapib-thiol between 200 and 700 ng/ml (0.63 μM to 2.2 μM).
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Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport.
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