Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-culture.

Angiogenesis · 2010 · PMC2980626 · PMID 20927579

Europe PMC DOI

hedged sentences

0.0586

closest p · 1.2× alpha

0.1102

boldest claim

The sentences

of borderline significanceP = 0.0586so close (0.05 < p ≤ 0.1)

Inhibition of HIF-1α stabilization by resveratrol was also associated with decreased VEGF expression; however the 62% decrease in A375 VEGF expression and 14% decrease in YUZAZ6 VEGF expression were of borderline significance (A375, P = 0.0586; YUZAZ6, P = 0.0651).

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a trend toward significanceP = 0.1102not close (p > 0.1)

Hypoxia was found to cause additional stabilization of HIF-1α in all three cell lines, but the degree of HIF-1α accumulation was found to be significant only for the A375 cell line ( P = 0.030) with a trend toward significance in the other lines (M14, P = 0.1102 and YUZAZ6, P = 0.0948).

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