Firstly, the coordinated responses observed in axenic culture may not be significant in the interaction of fungus and the immune system.
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Aspergillus fumigatus allergen expression is coordinately regulated in response to hydrogen peroxide and cyclic AMP.
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The sentences
The expression of allergens in response to an oxidative stress stimulus may be highly significant in presentation of the proteins to the immune system via antigen presenting cells such as macrophages or dendritic cells.