COMT Val158Met Polymorphism Modulates Cognitive Effects of Dietary Intervention.

The CR-induced improvement of memory score was considerably greater in COMT Val/Val -carriers than in Met -carriers, so that memory scores of both genotype groups were no longer significantly different from each other after the intervention ( post hoc t -test, p > 0.05); however t -test of changes in memory score failed to reach significance between groups ( p = 0.15).

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However, an interesting trend emerged for markers of inflammation: Diet-associated reductions in TNF-alpha levels after the intervention were more pronounced in Val/Val -carriers (Figure 5 ), however ANOVA RM failed to reach significance.

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