Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699.

Thus, the temozolomide-induced TGD of 28.5 days was extended to 46 days by co-administration of AG-014699, equivalent to a 61% increase in efficacy; however, this was not quite significant ( P =0.11 Mann–Whitney test).

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