Substrate reduction augments the efficacy of enzyme therapy in a mouse model of Fabry disease.

PLoS One · 2010 · PMC2991350 · PMID 21124789

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highly significantno p-value reported

The kidney and urine both showed highly significant improvements in GL-3 levels with either regimen of combination therapy (ERT2 or ERT4) when compared to the ERT alone group.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.