Genistein improves neuropathology and corrects behaviour in a mouse model of neurodegenerative metabolic disease.

Following genistein treatment, highly significant 31% reductions in LAMP2 staining were observed in the cortex ( Figure 1B,C,F ), 34% in the hippocampus ( Figure 1D ) as well as a significant 37% reduction in the pathogenic heparan sulphate stored in the brains of MPSIIIB mice ( Figure 1E ).

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