Spatio-temporal regulation of Wnt and retinoic acid signaling by tbx16/spadetail during zebrafish mesoderm differentiation.

In total, three lines of evidence suggest the presence of detectable signal in the 4/5-somite dataset, despite such high levels of noise: (1) downregulation of our positive control gene set (red blood cell-specific genes) was highly significant; (2) false-positives declined as fold-changes increased above 4-fold, indicating that our 4/5-somite array analyses can more accurately detect larger fold-changes; and (3) independent lines of evidence from other experimental systems are also beginning to link Wnt signaling with blood formation [ 48 - 50 ].

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