Uses and benefits of omega-3 ethyl esters in patients with cardiovascular disease.

We found that Omega-3 EE was associated with a 14% (OR 0.86; 95% CI 0.79–0.94) significant risk reduction of death from cardiac cause and with barely not statistically significant risk reduction of all cause mortality (odds ratio [OR] 0.92; 95% CI: 0.83–1.03) ( Figure 1 ), confirming findings reported by Leon et al. 38 Of note, the beneficial effects on risk of CV disease (CVD) appeared strong in the analysis of trials of secondary prevention, but not in those of the primary one. 39 This finding should be considered against the efficacy of omega-3 fatty acids in primary CVD prevention.

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