Aromatase is a direct target of FOXL2: C134W in granulosa cell tumors via a single highly conserved binding site in the ovarian specific promoter.

PLoS One · 2010 · PMC3004790 · PMID 21188138

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highly significantno p-value reported

This is highly significant as IRS are well documented to be bound by members of the FOXO subfamily of forkhead proteins [47] , [48] , [49] and members of this family play a key role in the regulation of ovarian follicle development [50] .

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