Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21.

As a result, the unconditional risk of the rs7687945 A allele (1.25) relative to the G allele (1.18) is 1.07 and not significantly different from 1.0 (Table 2 ), which explains the lack of marginally significant association at rs7687945.

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However, while the direction of effects is the same, the individual effects and marginal significance of the two SNPs differ somewhat in the discovery and replication data sets (Table 3 ), so we would recommend some caution pending further replication.

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