Encoded by about 15 active genes in the C57BL/6 mouse genome ( [15] and unpublished results), the IRG proteins function interactively and nonredundantly in resistance [16] , so that disruption of single members of the family cause highly significant early mortality following infection with avirulent strains [9] .
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Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii.
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