SIRT1 contributes to telomere maintenance and augments global homologous recombination.

Interestingly, when a similar analysis was performed on pericentromeric chromatin, we also observed decreased H3K9Ac, which almost reached significance, and a significant increase in H4K20me3 trimethylation ( Fig. 7, C and D ), which is suggestive of induction of a more heterochromatic state.

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In all cases, increased telomere length was accompanied by a significant decrease in the proportion of short telomeres (<30 kb) and an increase in the proportion of long telomeres (>80 kb); an almost significant decrease in SFEs was also observed in the SIRT1-tranfected SIRT1 −/− MEFs ( Fig. 1 F ).

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