highly significantP <0.00001
Indeed, when analyzing original single-cell time series data from the study reported by Yamaguchi et al (2003) , we also find a substantial (about threefold) and highly significant reduction of relative amplitude upon TTX treatment ( P <0.00001; Mann–Whitney test, one-tailed; n =78 for untreated cells; n =185 for TTX-treated cells; not shown)—very different from the effects of MDL on relative amplitude.