highly significantP < 0.001
In the overall population, median PFS was 4.90 months (95% CI, 3.98–5.52 months) with everolimus and 1.87 months (95% CI, 1.84–1.94 months) with placebo, translating into a highly significant HR of 0.33 (95% CI, 0.25–0.43; P < 0.001; Fig. 1 B).