Reduced Interhemispheric Functional Connectivity in the Motor Cortex during Rest in Limb-Onset Amyotrophic Lateral Sclerosis.

Front Syst Neurosci · 2010 · PMC3018774 · PMID 21228916

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp < 7 × 10 −26actually significant

Resting-state functional connectivity Group comparisons of interhemispheric motor cortex BOLD signal r -coefficients, including all ROI pairs, resulted in highly significant K–S differences ( D ) between ALS and healthy participants ( D = 0.19, p < 7 × 10 −26 ) with ALS being less connected overall than healthy controls (see Figures 3 and 4 ).

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a trend toward significancep = 0.07so close (0.05 < p ≤ 0.1)

There was a trend toward significance between months since onset and ALSFRS-r scores ( r = 0.41, p = 0.07) and an even stronger trend between months since onset and CBS scores ( r = 0.62, p = 0.058).

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reached near significancep = 0.08so close (0.05 < p ≤ 0.1)

In this model, hand strength disparity significantly predicted dorsal ROI connectivity, t (19) = −2.22, p = 0.04, and question 4 reached near significance, t (19) = 1.81, p = 0.08.

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