Antibacterial activity of the contact and complement systems is blocked by SIC, a protein secreted by Streptococcus pyogenes.

J Biol Chem · 2011 · PMC3020741 · PMID 21068386

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highly significantno p-value reported

After 6 and 8 h, the Mann-Whitney U test showed a highly significant growth advantage for wild-type AP1 as compared with the SIC mutant, data supporting the notion that SIC promotes bacterial survival in human plasma.

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