Understanding protein evolutionary rate by integrating gene co-expression with protein interactions.

In addition, the partial Spearman correlation coefficients between PPID and protein evolutionary rate are still significant (though marginally significant in the "Combined-AP/MS" dataset) after controlling for protein abundance (column 4 of Table 3 ), with the exception of "Y2H-union" datasets, suggesting that PPID contains independent information for evolutionary rate (similar results were obtained when using other expression-related data [ 34 - 36 ], data not shown).

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To account for the non-normality of the distribution of PPID, we also computed Spearman rank correlation between PPID and protein evolutionary rate and found that the correlations are highly significant in all the six datasets except "Y2H-union" (column 3 of Table 1 ).

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