Barely Significant
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The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA.

BMC Biol · 2010 · PMC3022773 · PMID 21176148

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The sentences

highly significantP -value < 10 -16actually significant
However, the overlap between the two categories of the interagency transcribed regions is highly significant ( P -value < 10 -16 , chi-square test).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.