Phylogenomics of phosphoinositide lipid kinases: perspectives on the evolution of second messenger signaling and drug discovery.

BMC Evol Biol · 2011 · PMC3024228 · PMID 21208444

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an overall trendno p-value reported

However, there is an overall trend for compounds with broad Class I PI3K spectrum to inhibit other PIKs as well as more distantly related kinases.

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