TF-centered downstream gene set enrichment analysis: Inference of causal regulators by integrating TF-DNA interactions and protein post-translational modifications information.

When PTM-mediated direct model was used, the overlaps between the observed DEGs and the expected targets of SNF1 were highly significant (Table 1 , p-value<=0.001), while the number of the overlap was 0 (p-value=1) when other models were used.

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