Barely Significant
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From L-dopa to dihydroxyphenylacetaldehyde: a toxic biochemical pathway plays a vital physiological function in insects.

PLoS One · 2011 · PMC3026038 · PMID 21283636

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highly significantno p-value reported
Although it is far from a comprehensive understanding in terms of the detailed biochemical processes, pathways, and chemical mechanisms of DHPAA synthase-mediated flexible insect cuticle formation, data present in this communication are highly significant in that they provide practical insights into designing experiments that will lead to a comprehensive understanding of the DHPAA synthase in insect cuticle formation.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.