Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes.

In addition, MLDS-treated PancMet KO mice displayed a nonsignificant trend toward faster and higher frequency of hyperglycemia compared with WT mice ( Fig. 3 B ).These results correlated with significant hypoinsulinemia in PancMet KO mice at day 20 after the first STZ injection compared with the reduced insulin levels in WT mice treated with MLDS ( Fig. 3 C ).

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