Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation.

PLoS One · 2011 · PMC3031616 · PMID 21304957

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A significantly attenuated neurotoxicity in nontransgenic mice (i.e., very little loss of dopaminergic neurons with the dose of MPTP causing ∼50% reduction in our study) observed in this study suggest that there may be significant strain background and/or other transgene specific effects [27] .

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