Barely Significant
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The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42.

Br J Cancer · 2011 · PMC3031889 · PMID 21139582

Europe PMCDOI
1
hedged sentence
0.0010
closest p · 0.0× alpha
0.0010
boldest claim

The sentences

highly significantP =0.001actually significant
Furthermore, since silencing expression of either Tip-1 or GEF16 produced a highly significant ( P =0.001) reduction in Cdc42 activation in T16 E6-expressing cells, this provides clear evidence that these two proteins are involved with the ability of T16 E6 to upregulate Cdc42 activation in cells.

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