Protein kinase Cθ is required for cardiomyocyte survival and cardiac remodeling.

Quantification of the fibrosis areas at different time points during postnatal life showed that in newborn mice, there was no significant increase in fibrosis in the LVs of either genotype; by contrast, a highly significant increase in the accumulation of interstitial fibrosis in PKC θ −/− mice was observed with age, when compared with age-matched WT mice ( Figure 2C ).

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