Barely Significant
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Internet-based treatment for older adults with depression and co-morbid cardiovascular disease: protocol for a randomised, double-blind, placebo controlled trial.

BMC Psychiatry · 2011 · PMC3034669 · PMID 21232162

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highly significantno p-value reported
Furthermore, treatments are typically targeted only at those with major depressive disorder although the public health impact of lesser symptom severity is highly significant [ 3 , 4 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.