Specific age-associated DNA methylation changes in human dermal fibroblasts.

PLoS One · 2011 · PMC3035656 · PMID 21347436

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highly significantno p-value reported

In contrast to MSC, fibroblasts could not be induced towards adipogenic, osteogenic and chondrogenic lineage and this is reflected by highly significant differences between the two cell types: 766 CpG sites were hyper-methylated and 752 CpG sites were hypo-methylated in fibroblasts in comparison to MSC.

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