MiR-34a has a highly significant tumor suppressor effect in an orthotopic mouse model of neuroblastoma Although the role of miR-34a as a potential therapeutic in vivo has been studied in models of colon cancer [ 13 ], lung cancer [ 26 ] and glioblastoma[ 25 ] to date the ability of miR-34a to inhibit neuroblastoma cell growth has thus far only been investigated in vitro .
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MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma.
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