Selective ERK activation differentiates mouse and human tolerogenic dendritic cells, expands antigen-specific regulatory T cells, and suppresses experimental inflammatory arthritis.

First, we confirmed that a highly significant reduction of OVA-specific CD8 T cells was achieved only when active MEK-1 and IiOVA were simultaneously expressed from the same lentivector backbone, with a reduction from 500 spots per million splenocytes down to ∼40 spots per million splenocytes, as assessed by IFNγ ELISpot assay ( Figure 1A ).

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