Modification of the L1-CAM carboxy-terminus in pancreatic adenocarcinoma cells.

This is highly significant since glutamine–glutamate modification has been shown to regulate receptor multimerization, putatively by reducing electrostatic repulsion between helices [ 33 ], and similar mechanisms have been proposed for asparagine–aspartate conversion including the regulation of peptide hormone dimerization [ 34 ] and activation of extracellular matrix molecules [ 35 ].

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