A genome-wide association scan on estrogen receptor-negative breast cancer.

Nevertheless, when we relaxed the P -value cut-off in the training dataset to 0.5, the Swedish ER-positive breast cancer target dataset showed borderline significance for a shared polygenic component with ER-positive breast cancer, based on the Finnish ER-positive training dataset (Figure 10a , P = 0.066).

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Due to the large number of markers evaluated in a genome-wide scan, signals with small effects and modestly significant P -values are likely to be dismissed after the correction of multiple testing.

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The focal adhesion pathway (hsa04510) was found to be marginally significant ( P α = 0.05 = 0.052).

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