There was a zero-order positive correlation between hippocampal activity to the nonpredictive CS versus the safe room CS and trait anxiety, r(21) = 0.53, p < 0.01, and a nonsignificant trend toward a negative relationship between sustained hippocampal activity during the unpredictable room versus the predictable room and trait anxiety, r(21) = –0.32, p = 0.14, 2-tailed.
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Fear-conditioning mechanisms associated with trait vulnerability to anxiety in humans.
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