Update on the management of chronic eczema: new approaches and emerging treatment options.

88 In a multicenter, double-blind, placebo-controlled crossover study involving 33 patients with severe chronic atopic dermatitis, therapy with cyclosporine for 8 weeks was associated with highly significant improvement of quality of life parameters by multiple clinical indices. 92 In a randomized double-blind trial of 38 adults with severe eczema, cyclosporine (2.7–4 mg/kg/day for 6 weeks) was significantly more effective than prednisolone (0.5–0.8 mg/kg/day for 2 weeks) in achieving a stable remission, with 6/17 patients on cyclosporine remaining clear 12 weeks after active treatment compared to 1/21 patients on prednisolone. 93 Cyclosporine therapy is generally associated with a rapid response.

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