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HE4 and CA125 as a diagnostic test in ovarian cancer: prospective validation of the Risk of Ovarian Malignancy Algorithm.

Br J Cancer · 2011 · PMC3048204 · PMID 21304524

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a definite trendno p-value reported
A definite trend could be seen from stage I to stage IV disease, and CA125 and HE4 performed significantly worse when early and late stages of disease were compared.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.