A prospective study of chemotherapy-induced febrile neutropenia in the South West London Cancer Network. Interpretation of study results in light of NCAG/NCEPOD findings.

A meta-analysis ( Clark et al , 2005 ) showed a significant reduction in the length of hospitalisation (hazard ratio: 0.63, 95% CI: 0.49–0.82, P =0.0006) with the use of G-CSF, but only a marginally significant decrease in infection-related mortality (odds ratio: 0.51, 95% CI: 0.26–1.00, P =0.05) and no significant reduction in overall mortality.

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As time is a highly significant factor in the successful management of neutropenic sepsis, a network-based protocol would aid in expediting assessment and early treatment.

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