According to [ 12 ], their aa-binding sites are of the three types: - Sites in which cognate codon and anticodon are both significantly over-represented, this group including arginine, isoleucine and (borderline significant) tyrosine. - Sites in which only cognate anticodons are found in significant excess, this group including histidine, phenylalanine and tryptophan. - Sites in which neither anticodons nor codons significantly dominate, this group including glutamine and presumably leucine.
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Histidine This amino acid shows an excess of its GUG (highly significant) and AUG (borderline significant) anticodons in aa-binding sites of selexed RNA aptamers [ 12 ].
on at their 3 rd and 1 st nts, charging tRNAs with cognate amino acids by p-aaRSs, etc.) However, Table 1 in [ 12 ] unambiguously shows that the codon(1-2)/anticodon(2-3) cases, but not their codon(2-3)/anticodon(1-2) "counterparts", are over-represented at significant level in Arg-, Ile- and (with borderline significance) Tyr-binding sites.