When are new hippocampal neurons, born in the adult brain, integrated into the network that processes spatial information?

When we estimated the proportion of BrdU-positive cells that respond to spatial exploration by expressing Arc over the course of the animal's life span, we found a highly significant linear regression; thus, our hypothesis is that neurons born in the adult DG after day 301 do not respond to exploration anymore; this does not suggest that new neurons lose their integration within the network but rather that they can no longer be recruited into circuits that process spatial information ( Fig. 5A ), which may be related to a network mechanism that ensures that the DG code for spatial information can change.

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