A notable trend is that those studies finding decreased levels of activity in ε 4 carriers frequently did so in regions commonly associated with AD (e.g., posterior cingulate, precuneus, and hippocampus), while studies finding increased activity in ε 4 carriers commonly did so in regions beyond those typically involved in early AD (e.g., prefrontal cortex).
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The apolipoprotein e antagonistic pleiotropy hypothesis: review and recommendations.
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